Chronic Pain affects over 50 million adult Americans and remains one of the most common reasons for seeking medical care. Spinal Cord Stimulation (SCS) is an FDA-approved neuromodulation therapy used to treat chronic, refractory pain. While SCS is widely utilized, there are currently no objective tools to measure its effectiveness in patients with chronic pain. Moreover, Patient Responses to SCS Vary Significantly, and there is no established consensus on optimal stimulation parameters or device selection. To address these challenges, our research integrates Perioperative Electrophysiology—including EEG, ECG, eye tracking, and wearable sensors—with Advanced Signal Processing, Machine Learning, and neuromodulation techniques. Our goal is to identify Neural Correlates of Chronic Pain and develop Quantitative, Objective Measures for its assessment. This work aims to transform chronic pain management and support the development of Next-Generation Medical Technologies that personalize and optimize treatment.
